Ganoderma lucidum
Reishi
400+ triterpenes quiet cortisol and prepare the nervous system for deep, restorative overnight repair.
COP 120.000
60 Capsules · 1 Month Supply
How to Use
30 to 60 minutes before bed
1,000mg of triterpene-rich extract
A light snack improves triterpenoid absorption
Take each evening before bed. Triterpenes lower cortisol and support deep recovery through the night. Nightly use compounds.
What it does
for you
Calm
Over 400 triterpenes modulate cortisol response, quieting the nervous system.
Restoration
Deep immune and cellular repair while you sleep. Triterpenes continue working through the night.
Balance
Polysaccharides adapt to what your body needs: calming when stressed, lifting when depleted.
Evening Ritual
Take it at night. Cortisol drops, recovery starts.
Extraction
12:1 Dual Extract
Hot water and alcohol dual extraction preserves both water-soluble and fat-soluble actives.
Verified
Third-Party Tested
Every batch is independently tested for potency, heavy metals, pesticides, and microbials.
Purity
Zero Fillers
No maltodextrin, no mycelium grain, no additives. Pure fruiting body extract. Nothing else.
The Research
It regulates in both directions
A sluggish immune system needs stimulation. An overactive one, as in chronic inflammation or autoimmune conditions, needs calming. Reishi does both. That bidirectional modulation is rare. Most supplements only push in one direction.
It works through your gut, not your brain
Reishi does not sedate you. A 2019 study found its polysaccharides improve sleep by increasing gut bacteria that produce more serotonin, the direct precursor to melatonin. The improvement takes longer to feel and longer to fade.
130 anti-inflammatory compounds
Reishi contains over 130 distinct ganoderic acids, more bioactive triterpenes than any other known fungus. Some inhibit histamine release. Others block NF-kB, the molecular switch that triggers systemic inflammation. That range is why its effects span so many conditions.
Your cells are aging by the millimetre
Every time a cell divides, your telomeres get slightly shorter. Telomere length is one of the strongest predictors of biological age. Reishi polysaccharides have been shown in cell studies to inhibit that shortening.
Your liver is taking note
Multiple clinical trials show Reishi extracts reduce elevated ALT and AST, the enzymes that signal liver stress and damage. If you drink regularly, take medications, or simply want your liver working at full capacity, that finding is directly relevant to you.
The cortisol mechanism is documented
Reishi's adaptogenic reputation has a specific molecular basis. Ganoderic acids bind to corticosteroid receptors and modulate the HPA axis, reducing excess cortisol under chronic stress. Studies show significant reductions in the cortisol-to-DHEA ratio: the primary biochemical marker of accumulated stress burden.
Fifteen distinct antiviral compounds identified
Researchers have isolated more than 15 individual antiviral compounds from Reishi fruiting body. Ganoderic acid beta inhibits HIV-1 protease. Ganoderiol F is active against herpes simplex. Several lanostane-type triterpenes show broad antiviral activity. These are independent of its immune modulation effects.
It activates your immune system's first responders
Natural Killer cells are your immune system's rapid-response unit. They identify and destroy virus-infected and abnormal cells without needing prior antigen exposure or instructions from other immune cells. Reishi polysaccharides, specifically the beta-1,3-D-glucan fractions, have been shown in multiple human trials to significantly increase NK cell activity within 10 to 14 days of supplementation.
What They're Saying
“I am so impressed with setasouls!! been using the reishi for a week and sleeping soo much better tbh 🍄✨”
Sofia M. · Verified Buyer
“my partner actually noticed i seem calmer since i started reishi. that says a lot 😅”
Andrés F. · Verified Buyer
